Possibly the funniest line ever,

regarding the bloviating performed by Rosie O'Donnell on the View, with the line,

"My own sense of embarrassment at sharing a species with these women"

Nearly as good was his nomination for the new species of "North American Dumb Cow", in reference to that woman (not sure that is the appropriate use of the word, but that's what I'm sticking with).

Almost wet myself after reading that.